Dentistry

Oral Genetics1

Genética Oral

Course code:9548220

Fernando Guilherme Prior Ferraz

Learning outcomes of the curricular unit:

Medical Genetics is nowadays one of the most advanced areas of biology and medicine. The spectacular advances in molecular biology, such as technologies within the recombinant DNA, the use of molecular probes for the detection of multiple polymorphisms and more recently the enzymatic amplification " in vitro " DNA, started a revolution within the Genetics and consequently, in the practice of medicine itself. New models emerged in the medical practice, where clinical genetics plays a very important role; as a result that started to be known the genetic basis of many common diseases. The power of modern molecular analysis comes from the fact that the clinical experience of the mysteries of life begin to be explained in precise molecular terms.
The objective of the discipline of genetics will be to prepare students to understand the importance and significance of normal and pathological variation, giving them the knowledge of the most used technologies in this area.

Syllabus:
  1. Introduction to "clinical genetics": genes, characters and genealogy.
  2. Development/evolution.
  3. DNA structure and replication.
  4. Action of genes - maintenance of genetic information.
  5. Gene mutation.
  6. Chromosome structure and function.
  7. Chromosomopathy: aneuploidy and other chromosomal abnormalities.
  8. The genetics of cancer.
  9. New applications in clinical genetics.
Suggested Bibliography:
  • Strachan T & Read AP (2011) Human Molecular Genetics. 4th ed., Garland Science/Taylor & Francis Group. ISBN: 0815341490, 9780815341499.
  • Gelehrter T & Collins F (1992) Principes de Genetique Moleculaire et Medicale Gelehrter. 2nd ed., Pradel. ISBN 13: 978-2907516273.
  • Snustad DP & Simmons MJ (2011) Principles of Genetics. 6th ed., John Wiley & Sons. ISBN-13: 978-0470903599.