Drugs of Abuse II
Substâncias de Abuso II
Course code:8059221
Maria Edite da Silva Oliveira Torres
Learning outcomes of the curricular unit:
The competencies of Interpretation, evaluation and presentation of the evidence as competence of laboratory analysis are presented as the learning objectives (LO), and are:
- To know how to explain the analytical techniques globally, to understand the parameters involved in the selection of the method and to know how to select an analytical strategy for a given scenario
- To analyze and discuss critically the possible techniques for laboratory analysis of substances of abuse
- Know how to use the computer software related to the equipment
- To be aware of the availability and know how to use databases that support the interpretation of analytical data related to the characteristics of substances of abuse
- To know the classification systems of substances of abuse as well as the neurochemical mechanisms that characterize the associated toxicological phenomena, namely those involving tolerance and dependency syndromes
- To acquire knowledge on international and national legislation applied to this subject
Syllabus:
- Substances of abuse of the psychoanalytic group: origins, pharmacotoxicology, modes of action, consumption profiles and analytical methodologies for characterization.
- Substances of abuse of the group of psychodysleptics: origins, pharmacotoxicology, modes of action, consumption profiles and analytical methodologies for characterization.
- Synthetic and uncontrolled drugs, with widespread expression of increased consumption and strategies for their control.
- Introduction of fundamental concepts of Toxicology of drugs of abuse as complementary data to those of pharmacology previously taught.
- Importance of dose/response relationships, interactions, various types of tolerance and associated dependency profiles.
- Methodological knowledge of intervention, from the simple analytical approach of characterization and quantification in biological and / or solid samples, to the more complex methodologies of chemical characterization of drug batches (drug profiling).
Suggested Bibliography:
- Karch BS, Drummer OH (2015) Karch’s Pathology of Drug Abuse. CRC Press. 5th Ed. ISBN: 978-1-43986-146-2
- Karch SB (2007) Drug abuse handbook, 2nd ed., Taylor & Francis Group, CRC Press. ISBN-13: 978-0-8493-1690-6
- Karch BS (2008) Pharmacokinetics and pharmacodynamics of abused drugs. New York: Taylor & Francis Group, LLC. ISBN: 13: 978-1-4200-5458-3
- Jickells S & Nefrusz A (2008) Clarke’s analytical forensic toxicology, Pharmaceutical Press, London. ISBN: 9780853697053
- Cole MD (2004) The Analysis of controlled substances, WileyBlackwell. ISBN-10: 0471492523