Forensic Sci.

Forensic Toxicology2

Toxicologia Forense

Course code:8059312

Mário João Rodrigues Dias

Learning outcomes of the curricular unit:

This CU intends to show the application of the principles of General Toxicology and of the Analytical Methodologies to the Forensic Toxicology.

  • Theoretical aspects on ADME and toxicokinetics of different toxic agents, as well as about the analytical methodologies for their detection in different matrices.
  • It is intended to show the student the characteristics of the different stages which are part of an toxicological investigation and that include the objective of the investigation/expertise, sampling, methodology of analyse and interpretation of results..
  • It is intended that the student acquires knowledge about the importance of the implementation on Forensic Toxicology Laboratories of an Internal and External Quality Control, of a Quality Management System and the Accreditation by ISO/EN/17025.
  • It is intended a characterization of toxicological investigation in several areas of application of the Forensic Toxicology, according to the approach defined in OA2.
Syllabus:
  1. GENERAL PRINCIPLES IN TOXICOLGY
  2. TOXIC RESPONSE
  3. TOXIC AGENTS (ADME/TOXICITY)
  4. ANALYTICAL METHODS USED IN TOXICOLGICAL INVESTIGATIONS
  5. STAGES OF A TOXICOLOGICAL INVESTIGATION
  6. QUALITY MANAGEMENT IN FORENSIC TOXICOLOGY LABORATORIES
  7. AREAS OF APPLICATION OF THE FORENSIC TOXICOLOGY
 
Suggested Bibliography:
  • Klaassen CD (2013) Casarett & Doull’s. Toxicology ‐ The Basic Science of Poisons, 8th ed., McGraw‐Hill, USA. ISBN: 978-0-07-176923-5
  • Ioannides C (2001) Enzyme systems that metabolize drugs and other xenobiotics, Chichester: John Wiley & Sons Ltd. ISBN: 0-471-89466-4
  • Jickells S & Nefrusz A (2008) Clarke’s analytical forensic toxicology, Pharmaceutical Press, London. ISBN: 978-0-85369-705-3
  • Birkett DJ (2002) Pharmacokinetics Made Easy, 2nd ed., McGraw-Hill, Sidney. ISBN: 978-0-074-71072-2
  • Jackson ARW & Jackson JM (2008) Forensic Science, 2nd ed., Pearson Education Limited. ISBN: 978-0-13-199880-3